Board Of The Week
Believe it or not the we still use blackboards, as opposed to whiteboards, a great deal when developing our research. It harks back to our teaching days when there was only blackboards to write on and are still pretty much standard in every mathematics department in the UK. Also unlike markers chalk always works! Here we will present a selection of boards that highlight research very much in development and discuss them briefly on a weekly basis.
Mapping Genotype to Phenotype
How do microenvironmental perturbations impact phenotypic responses?
One of the outstanding fundamental questions in cancer biology is how to directly link the current wealth of genetic data, not only with clinical outcome, but crucially with the cellular phenotype. The so-called genotype-phenotype mapping is at the heart of our understanding of many of the engines that drive tumor growth and progression. Here we were attempting to understand this mapping via a systematic set of microenvironmental perturbations (mainly drug driven) on a set of cell lines with known genetic mutations and monitoring the phenotypic reponse.
Up and coming boards...
A critical question in drug resistence centes on wether a resistant population already exists or evolves.
Using EGT to understand interactions between microenvironment dependent/independent tumor populations.
Understanding Metastatic Spread
By viewing the vascular system and organs as a network of conneceted nodes.