Published: a survey of open questions in adaptive therapy
Our paper, “A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation ” was published in eLife.
The first figure from the paper, above, captures the essence of the review: highlighting 11 open questions in cancer adaptive therapy mathematical modeling. The questions are split into three sections: (1) integrating the appropriate components into mathematical models (2) design and validation of dosing protocols, and (3) challenges and opportunities in clinical translation.
To aid in addressing future questions, we also outline the history of mathematical modeling in the field of adaptive therapy. As you can see, the figure below shows a selection of influential papers and key clinical trials leading to advancements in the field of adaptive or evolution-based treatment. This figure illustrates that experimental and clinical investigation of adaptive therapy has progressed synergistically with mathematical and computational modeling.