March 14, 2018

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Grants and Funding Opportunities  |  Lab 360 | Seminars and Events


(NEW) Moffitt Study Published in Scientific Reports

Drug therapies that target a specific molecule have changed the way patients are treated for cancer and greatly improved survival rates. However, some patients do not respond to these therapies because the drug is not reaching the tumor cells effectively. In a new study published in Scientific Reports, Moffitt researchers combined single-cell imaging of cancer cells in mice with mathematical modeling to determine which drug characteristics are the most important for efficient drug uptake.

The standard methods that scientists use to study drug uptake are based on the idea that a tumor and its surroundings have uniform characteristics. However, this assumption is inaccurate and may lead to a one-size-fits-all approach to treatment. The Moffitt research team, which included Kasia Rejniak, Aleksandra Karolak, David L. Morse, Veronica Estrella, Amanda Huynh and Tingan Chen, wanted to take a different approach to study drug uptake. They used mathematical modeling and imaging techniques that allowed them to track and predict the ability of a single cell to take up a drug. Within their model, they compared different drug characteristics and tumor properties to determine which conditions lead to more effective drug uptake by a cell.

They discovered that the amount of drug that binds to a cell is dependent on how quickly a drug diffused through the tissue rather than on the concentration of drug that enters the tissue. Drugs that diffused quickly tended to bind more effectively to cells that were further away from blood vessels. Alternatively, drugs that diffused slowly tended to bind to cells that were closer to blood vessels and were more effective when the cells were tightly packed. The researchers also showed that drugs that are released quickly are able to bind more effectively to cells with different levels of drug receptors.

Study Article | News Release

(UPDATED) Added Security for Moffitt Webmail

Outlook Web App (OWA), or Webmail, is going to require a second method of authentication in addition to standard network credentials. This will be achieved with a DUO account. DUO is a mobile app that provides a second level of authentication to verify identity.

In recent months, Moffitt email has been repeatedly infiltrated by third parties who used access to our email system to send internal and external spam emails. Protection against cyber-attacks like these requires a robust infrastructure and implementation of industry-standard best practices for remote access points. Starting in mid-April, team members will be required to use two-factor authentication when accessing OWA. This means that logging into OWA will require both network credentials and DUO verification.

If you do not have a DUO account, you will need to submit an iStar ticket via the Moffitt Service Portal. You can find the right ticket under IT Service Desk > Applications & Software > Request Webmail Access.

Grants and Funding Announcements

(NEW) Medical Marijuana Research and Education Funding Opportunity

The State of Florida approved legislation and provided funding for the creation of the Medical Marijuana Research and Education (MMRE) Coalition. As stated in legislative statute 1004.4351, the purpose of the Coalition is to conduct rigorous scientific research, provide education, disseminate research, and guide policy development for the adoption of a statewide policy for the medical use of marijuana. For more information, please visit the Coalition for Medical Marijuana Research and Education website.

The State of Florida's MMRE Program invites investigators to apply for pilot funding for research and education projects. Research and education funding opportunities are available to all academic and research institutions in the State of Florida. Applications may request up to $200,000 in Direct Costs ($230,000 total costs). Full applications are due April 12 at 5:00 p.m.

Funding Guidelines and Application

(NEW) Florida Blue Foundation Grant Opportunity

The Advance Innovation and Promote Solutions in the Health Care System Program is seeking projects that support one or both of the following:

• Innovative ideas and programs that propose evidence-based, best practices models for new health solutions serving underserved, underinsured and low-income populations.
• Access to affordable, non-traditional health service delivery, such as telehealth.

The Florida Blue Foundation will award three-year and four-year grants. The average amount per year is $80,000 - 100,000.

Applicants must be currently providing health services to the underserved, underinsured and low-income populations. They must also have a five-year track record in the field and have the capability to reach the target populations mentioned above.

This is a restricted submission and Moffitt will have the opportunity to submit one application. Pre-applications should include a one-page letter of introduction and two-page outline emailed in PDF format to Maureen Ahearn by March 21. Pre-applications will be reviewed internally by REX. The final submission to The Florida Blue Foundation is April 20.

(NEW) Forbeck Foundation Scholar Opportunity

The William Guy Forbeck Research Foundation invites junior or postdoctoral fellows to apply to be a Forbeck Foundation Scholar and attend its annual Foundation Forum. Scholars are required to attend the annual forum their first year and attend scholar retreats for four years. During retreat meetings, scholars interact with peers and meet different groups of international experts in oncology. Scholars also have opportunities to apply for other programs sponsored by WGFRF that are only open to scholars and past meeting participants.

Due Dates: April 2 (sponsor receipt date)
Eligibility: Postdoctoral fellows, clinicians within the first four years of appointment as independent investigators. Must be able to attend the 2018 Annual Forum. There are no citizenship requirements, but scholars must be able to communicate in English.
Funding: WGFRF covers expenses to attend the meetings and offers a stipend to individuals at the end of their tenure period.
Contact: Lauren Roadman
How to Apply: Application, mail to

V Foundation Translational Research Grant Opportunity

The V Foundation for Cancer Research has announced a funding opportunity for translational research projects that brings together pre-clinical and clinical investigators. Translational projects should move a novel strategy from the laboratory into a human clinical trial or use specimens from a clinical trial to develop biomarkers or mechanisms. Research projects that focus on the biological basis of cancer are also encouraged.

This is a restricted submission and Moffitt will have the opportunity to submit two applications. Pre-applications should include a one-page letter of introduction and two-page outline emailed in PDF format to Maureen Ahearn by March 21. Pre-applications will be reviewed internally by REX. The final submission to the V Foundation will be May 30.

American Cancer Society - Institutional Research Grant Funding Opportunity

Moffitt Cancer Center is pleased to announce pilot funding opportunities to support junior faculty in initiating cancer-related research projects that assist them in competing successfully for national research grants. The maximum award amount is up to $30,000 for 12 months. The deadline is April 16 at 4:00 p.m.

For additional information, please contact Maureen Ahearn, x8824.

Guidelines | Application

Pediatric SU2C Catalyst Grant Funding Opportunity

The Pediatric SU2C Catalyst grant supports preclinical research and early phase clinical trials to provide foundational data that will allow pediatric trials to progress in parallel to adult clinical trials. Applications are encouraged to include a combination of therapies and/or devices for refractory pediatric cancers, and collaborations involving multiple companies are welcome. All applications must include inter-institutional collaborations.

Due Dates: April 5 (OSR) | April 9 (Sponsor) by 12:00 p.m. EST
Eligibility: • Team leader, team co-leader and team principals must have doctoral or medical degree and be independent investigators.
• Team leader will be primary contact and must be identified as having expertise in pre-clinical, clinical or translational research.
• Team co-leader must have expertise in different area from team leader.
• If project requests funding for a clinical trial, team leader or team co-leader must be the clinical leader for the team.
Funding: $3 million (total) - 4 years
Contact: Office of Sponsored Research, x6804
Links: Program Guide
Spreadsheet Templates
Application Submission Site
SU2C Catalyst

Research Lab 360: Cores, Labs, and Space

SRB Atrium Floor Update

The Design and Construction Team will wrap up phase one of the flooring project. The barricade has now moved into phase two.

As a reminder, this project is broken into five phases. Each phase lasts five to six weeks. Phase two will begin Saturday, March 10 and is scheduled to be complete on Wednesday, April 11.
Once the barricade is moved for phase two, the atrium will be accessible from the Magnolia Drive entrance.

It is important to note that the David Murphey and Ferman Family conference rooms will be accessible throughout the entire project.

If you have any questions, please contact Cheryl Bartolomeo, Manager of Business Operations, x8116.

Construction Schedule | Phasing Sketch

Seminars and Events

March Cancer Epidemiology Teas, Contact Suellen Sachariat
The CE Teas provide an informal setting for discussion of a spectrum of topics (e.g., novel research ideas, troubleshooting, the latest published findings, obstacles to the scientific/academic process, others' ongoing research).  
March 15, 2:00 -3:00 p.m.
March 23, 9:30 - 10:30 a.m.
March 29, 11:00 a.m. - 12:00 p.m.
March 19 - Molecular Oncology Faculty Candidate Seminar, Contact Kristen Gilpin
Michalina Janiszewska, PhD, Instructor of Medicine, Dana-Farber Cancer Institute, Boston, MA
Intratumor Heterogeneity, Topology and Therapeutic Resistance
11:00 a.m. - 12:00 p.m., Stabile Research Building, Ferman Family Conference Room

Calendar | Flyer
(NEW) March 20 - Department of Health Outcomes and Behavior Faculty Candidate, Contact Brenda Medero
Claudia Trudel-Fitzgerald, PhD, Research Associate and Clinical Psychologist, Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA
Psychological Factors In Cancer: Adaptation and Beyond
9:30 - 10:30 a.m., Stabile Research Building, David Murphey Conference Room

Calendar | Flyer
(NEW) March 20 - Department of Cancer Physiology Seminar, Contact Rachel Snayd
Juri G. Gelovani, MD, PhD, Professor of Oncology, Neurosurgery, OBGYN, Biomedical Engineer, Leader of Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI
Molecular Imaging of Histone Deacetylases
12:00 - 1:00 p.m., Stabile Research Building, Ferman Family Conference Room (Lunch provided to the first 65 attendees)

Calendar | Flyer
(NEW) March 21 - Molecular Oncology Research In Progress Seminar, Contact Kristen Gilpin
Marco Napoli, PhD, Postdoctoral Fellow in the Lab of Dr. Elsa Flores, Moffitt Cancer Center
Lucia Mazzacurati, PhD, Research Scientist in the Lab of Dr. Gary Reuther, Moffitt Cancer Center
Napoli: Oncogenic IncRNAs as Markers of Breast Cancer Progression
Mazzacurati: Targeting IGF1/Insulin Receptor Signaling to Overcome JAK2 Inhibitor Persistence in Myeloid Neoplasms
2:00 - 3:00 p.m., Stabile Research Building, David Murphey Conference Room (Refreshments will be provided)

Calendar | Flyer
March 23 - Educational Flow Cytometry Seminar, Contact Jodi Kroeger
Ramiro Diz, PhD, Application Specialist, ThermoFisher Scientific
Taking Your Flow Cytometry to the Next Level - Best Practices and Pitfalls to Avoid
10:00 - 11:00 a.m., Stabile Research Building, Ferman Family Conference Room

Calendar | Flyer
(NEW) March 27 - Center for Infection Research in Cancer Seminar, Contact Julie Rathwell
Wei-Zen Wei, PhD, Herrick Chair of Cancer Research, Barbara Ann Karmanos Cancer Institute, Professor of Oncology and Immunology/Microbiology, Wayne State University School of Medicine, Detroit, MI
Cancer Vaccine: Can It Work and How?
4:00 - 5:30 p.m., Moffitt Clinic Building, Owl's Den Room (Light refreshments will be served)

Calendar | Flyer
March 28 - Office of Postdoctoral Affairs Seminar, Contact Shonda Sterner
Brian Ruffell, PhD, Associate Member, Department of Immunology, Moffitt Cancer Center
Mark Alexandrow, PhD, Associate Member, Department of Molecular Oncology, Moffitt Cancer Center
Responsible Conduct of Research Series: Peer Review
12:00 - 1:00 p.m., Stabile Research Building, David Murphey Conference Room

Pre-Registration Required: To register via the Intranet, click on Quick Links, Learning Center, Search Catalog "Peer Review," click Details, Register. You will receive a calendar invite confirmation of your registration.

Calendar | Flyer
March 29 - Chemical Biology and Molecular Medicine Seminar, Contact Pamela Huntley
Peter Forsyth, MD, Chair, Department of Neuro-Oncology, Moffitt Cancer Center
Keiran Smalley, PhD, Director, Melanoma and Skin Cancers Center of Excellence, Moffitt Cancer Center
The Final Frontier: Melanoma in the Brain and Leptomeninges
8:00 - 9:00 a.m., Stabile Research Building, David Murphey Conference Room (Breakfast provided)

Calendar | Flyer
March 29 - OncLive State of the Science Summit: Breast Cancer, Contact Dayna Kleinstein
Join Dr. Hatem Soliman and OncLive for the State of the Science Summit on Breast Cancer. The summit is designed to educate healthcare professionals on the clinical benefits associated with new science driving new thinking in cancer management. Attendees will not only improve their knowledge of novel treatment approaches, but also leave the summit with the confidence and intent to apply state-of-the-art treatment strategies to care for their patients.
5:30 - 9:00 p.m., Hilton Tampa Downtown, 211 N. Tampa Street

Register | Flyer
(NEW) March 30 - Physical Sciences in Oncology Center Seminar, Contact Danae Paris
Olivier Elemento, PhD, Director, Englander Institute for Precision Medicine, Associate Director, Institute for Computational Biomedicine, Co-leader, Genetics, Epigenetics and Systems Biology Program, Meyer Cancer Center, New York, NY
A Cancer Precision Medicine Program Driven By Multi-omics, Analytics and Modeling
1:00 - 2:00 p.m., Stabile Research Building, Ferman Family Conference Room (Lunch will be provided to the first 50 attendees)

Calendar | Flyer
(NEW) April 4 - Molecular Oncology Research In Progress Seminar, Contact Kristen Gilpin
Leixang Yang, PhD, Research Scientist in the Lab of Dr. Jiandong Chen, Moffitt Cancer Center
Ella Box, Graduate Student in the Lab of Dr. Florian Karreth, Moffitt Cancer Center
Yang: Mutant p53 Sequestration of MDM2 Acidic and RING Domains Inhibits E3 Ligase Activity
Bok: Speedy Mouse Models for Melanoma Research
2:00 - 3:00 p.m., Stabile Research Building, David Murphey Conference Room (Refreshments will be provided)

Calendar | Flyer
(NEW) April 5 - Research APT Seminar Series, Contact Pamela Huntley
Ken Shain, PhD, MD, Assistant Member, Departments of Malignant Hematology and Tumor Biology, Moffitt Cancer Center
Mathematical Modeling in Multiple Myeloma: A Road To A Cure?
8:00 - 9:00 a.m., Stabile Research Building, David Murphey Conference Room (Breakfast provided)

Calendar | Flyer
(NEW) April 6 - Medical Oncology Grand Rounds, Contact Pamela Huntley
Ben Ho Park, MD, PhD, Associate Dean for Postdoctoral Affairs, Associate Director for Research Training and Education, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Breast Cancer Mutations as Therapeutic and Diagnostic Targets
8:00 - 9:00 a.m., Stabile Research Building, Ferman Family Conference Room (Breakfast provided)

Calendar | Flyer
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