Moffit WebsiteHome Page

Research pageTeam page

Contact page

Grants page

Instrumentation page publications pagelines

tab

Stuart Ember

 

 

 

 

Postdoctoral Fellow UK

Crystallography, Biochemistry, Molecular Biology

mail

Research

Postdoctoral Research Fellow: Drug Discovery Program H. Lee Moffitt Cancer & Research Institute, Tampa, FL USA. 2013 - Present

Research Associate: Department of Pathology, University of Cambridge, Cambridge United Kingdom. 2011 - 2013

Research Associate: Department of Medicine, Imperial College of London, London United Kingdom. 2009 - 2011

Graduate Research Assistant: Department of Pathway Medicine, University of Edinburgh, Edinburgh Scotland. 2007 - 2009

BSc (Honours) Student: Division of Infectios Diseases, University of Edinburgh, Edinburgh Scotland. 2006 - 2007

Education

Doctor of Philosophy in Biochemistry

Imperial College London, London, UK. 2009 - 2013

Bachelors of Science (Honours) in Biomedical Science

University of Edinburgh, Edinbugh, Scotland. 2003 - 2007

Publications

Mishra N. K, Urick A.K, Ember S. W, Schonbrunn E, & Pomerantz W.C.(2014) Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligan interactions. ACS. Chem. Biol. [Epub ahead of print]

Ember S. W, Zhu J. Y, Olesen S. H, Martin M. P, Becker A, Berndt N, Georg G.I & Schonbrunn E (2014). Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS. Chem. Biol. 19(5), 1160-1171

Smith G. L, Benfield C.T, Maluquer de Motes C, Mazzon M, Ember S.W, Ferguson B.J & Summer R.P (2013). Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity. J. Gen Virol. 94(11), 2367-2392.

Mazzon M, Peters N.E, Loenarz C, Krysztofinska E.M, Ember S.W, Ferguson B.J & Smith G.L (2013). A mechanism of induction of a hypoxis response by vaccinia virus. Proc. Natl. Acad. Sci. USA. 110(30), 12444012449

Ember S.W, Ren Hongwei, Ferguson B.J & Smith G.L (2012). Vaccinia virus protein C4 inhibits NF-kB activation and promotes viruse virulence. J. Gen. Virol. 93(10), 2098-2108.

Ember S.W, Schulze H, Ross A.J, Luby J, Khondoker M.R, Giraud G, Terry J.G, Ciani I, Crain J, Walton A.J, Mount A.R, Ghazal P, Bachmann T.T & Campbell C.J (2011). Fast DNA and protein microarray tests for the diagnosis of hepetitis C virus infection on a single platform. Anal. Bioanal. Chem. 401(8), 2549-2559

Schulze H, Ross A.J, Ember S.W, Mount A.R, Ghazal P, Khondoker M.R, Ciani I, Tlili C, Walton A.J, Terry J.G, Crain J, Bachmann T.T & Campbell C.J (2009). Peptide-tags for enhanced DNA microarray performance. Faraday. Discuss. 149, 201-210

Giraud G, Schulze H, Bachmann T.T, Campbell C.J, Mount A.R, Ghazal P, Khondoker M.R, Ross A.J, Ember S.W, Ciani I, Tlili C, Walton A.J, Terry J.G & Crain J (2009). Fluoresence lifetime imagining of quantum dot labeled DNS microarrays. Int. J. Mol. Sci. 10(4), 1930-1941.

Giraud G, Schulze H, Bachmann T.T, Campbell C.J, Mount A.R, Ghazal P, Khondoker M.R, Ross A.J, Ember S.W, Ciani I, Tlili C, Walton A.J, Terry J.G & Crain J (2009). Solution state hybridization detection using time-resolved fluoresence anistropy of quantum dot-DNA bioconjugates. Chem. Phys. Lett. 484(4-6), 309-314

Khondoker M.R, Backmann T.T, Mewissen M, Dickinson P, Dobrzelecki B, Campbell C.J, Mount A.R, Walton A.J, Crain J, Schulze H, Giraud G, Ross A.J, Ciani I, Ember S.W, Tlili C, Terry J.G, Grant E, McDonnell N, Ghazal P (2009). Multi-factorial analysis of class prediction error: estimating optimal number of biomarkers for various classification rules.J. Nioinform. Comput. Biol. 8(6), 945-965

Ember S.W, Ross A.J & Campbell C.J (2008). Developing microarray-based assays for blood typing and diagnosis of infectious diseases. Tecan Journal 3, 25-25

 

PDB Deposits

4QZS, 4O70, 4O71, 4O72, 4O74, 4O75, 4O76, 4O77, 4O78, 4O7A, 4O7B, 4O7C, 4O7E, 4O7F, 4PS5.

Resume

Professional Skills

X-ray Crystallography (data collection, processing and structure determination), drug discovery, protein production and purification using FPLC systems, biosensor assay development, DNA and protein microarray technologies, recombinant virus production, immunological assays and molecular biology (cloning, RT-PCR, mutagenesis

Awards

2014 Moffitt Postdoctoral Association Publication Award: 'Acetyl-lysine binding stie of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors'.

2014 Editor's Pick (American Chemical Society): 'Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacs with diverse kinase inhibitors'.

2013 Best Paper Award (International Journal of Molecular Science): 'Fluoresence lifetime imaging quantum dot labaled DNA microarrays'

2009 - 2012 Postgraduate Student Travel Grant (Society for General Microbiology)

Invited Presentations

2014 Moffitt Scientific Symposium, FL, USA: 'Bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors'.

2012 SGM Spring Conference, Ireland: 'Vaccinia virus strain Western Reserve protein C4 inhibits NF-kB signaling'.

Memberships

American Crystallographic Assosciation 2013 - Present

Society of General Microbiology 2009 - Present

TOP