Peer-reviewed publications
- Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence H, Engelman RW, Lawrence NJ and Mahajan NP*. Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer Journal of Biological Chemistry 2012. Pubmed ID:
- Mahajan K and Mahajan NP*. PI3K-independent AKT activation: A Treasure Trove of Novel Therapeutics Journal of Cellular Physiology 2012.Pubmed ID: 22307544
- Mahajan K, Coppola D, Lawrence H, Luo Y, Zhu W, Chen AJ, Lawrence NJ, Mahajan NP*. Ack1 correlates with pancreatic cancer progression 2012. American Journal of Pathology 180(4):1386-93, 2012. Pubmed ID: 22322295
- Lin HY, Park HY, Radlein S, Mahajan NP, Sellers TS, Zachariah B, Pow-Sang J, Coppola D, Ganapathy V, Park JY. SLC5A8 gene variation and protein levels in prostate cancer risk and aggressiveness. Urology 78:971e1-9, 2011. Pubmed ID: 20623637
- Mahajan K, Challa S, Coppola D, Lawrence H, Luo Y, Zhu W, Chen A, Lawrence NJ and Mahajan NP*. Effect of Ack1 Tyrosine Kinase Inhibitor on Ligand-Independent Androgen Receptor Activity. Prostate 70:1274-1285, 2010. Pubmed ID: 20623637
- Mahajan K and Mahajan NP*. Shepherding Androgen receptor and AKT by Ack1 in hormonally regulated cancers. Journal of Cellular Physiology 224:327-33, 2010. Pubmed ID: 20333297
- Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schonbrunn E, Sebti SM, Earp HS, Mahajan NP. Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation. PLoS One 5:e9646, 2010. Pubmed ID: 20333297
- Mahajan NP, Liu Y, Majumder S, Warren MR, Parker CE, Mohler JL, Earp HS, Whang YE. Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation. Proc Natl Acad Sci USA 104:8438-8443, 2007. Pubmed ID: 17494760
- Mahajan NP, Whang YE, Mohler JL, Earp HS. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer Research 65:10514-10523, 2005. Pubmed ID: 16288044
- Li Y, Mahajan NP, Webster-Cyriaque J, Bhende P, Hong GK, Earp HS, Kenney S. The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1. Journal of Virology 78:11778-11785, 2004. Pubmed ID: 15479819
- Mahajan NP, Earp HS. An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action. J Biol Chem. 278:42596-42603, 2003. Pubmed ID: 12920122
- Guttridge KL, Luft JC, Dawson TL, Kozlowska E, Mahajan NP, Varnum B, Earp HS. Mer receptor tyrosine kinase signaling: prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferation. J Biol Chem. 277:24057-24066, 2002. Pubmed ID: 11929866
- Mahajan K, Gangi-Peterson L, Sorscher D, Wang J, Gathy K, Mahajan NP, Reeves W, Mitchell B. Association of terminal deoxynucleotidyl transferase with Ku. Proc Natl Acad Sci USA. 96:13926-13931, 1999. Pubmed ID: 10570175
- Mahajan NP, Harrison-Shostak D, Michaux J, Herman B. Novel mutant green fluorescent protein protease substrates reveal the activation of specific caspases during apoptosis. Chemistry & Biology 6:401-409, 1999. Pubmed ID: 10375546
- Mahajan NP, Linder K, Berry G, Gordon G, Heim R, Herman B. Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer. Nature Biotechnology 16:547-552, 1998. Pubmed ID: 9624685
- Mahajan NP, Rao C. Nucleotide sequence and expression in E. coli of the complete P4 type VP4 from a G2 serotype human rotavirus. Arch Virol. 141:315-329, 1996. Pubmed ID: 8634023
- Zha H, Fisk H, Yaffe M, Mahajan N, Herman B, Reed J. Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol. 16:6494-6508, 1996. Pubmed ID: 8887678
Book Chapters
- Herman, B, Wang, X, Wodnicki, P, Perisamy A, Mahajan N, Berry G and Gordon G. Fluorescence Lifetime Imaging Microscopy. Applied Fluorescence in Chemistry, Biology and Medicine In: W. Rettig, B. Strehmel, S. Schrader and H. Seifert (Eds.), Springer Verlag Press, Berlin Heidelberg, 1998.
- Herman B, Mahajan N, Casanova E, Michaux J and Gordon G. Two fusion FRET: A new means to observe structural and functional protein dynamics in living cells. 3rd conference on fluorescence microscopy and fluorescent probes, 2000.
- Herman B, Gordon G, Mahajan N and Centonze V. Measurement of fluorescence resonance energy transfer in the optical microscope. Methods in Cellular Imaging In: Periasamy A (Ed.), Oxford University Press, New York, New York, 2001.
Patents
1. Title: AKT Tyrosine 176 Phosphorylation Cancer Biomarker
Serial # US2010/023487
Filing Date: February 8, 2010
• pTyr176-AKT antibodies are licensed to a Biotech Company, TechnoGenesys
2. Title: Antibodies specific for phosphorylated histones and uses thereof
Serial # 61/583,864
Filing Date: January 6, 2012
•