The major theme of our lab is to develop a mechanistic understanding of signaling pathways that drive lung cancer progression and develop new therapeutic approaches based on a more solid understanding of these pathways. The focus has been on kinase signaling and kinase inhibitors.
Major projects in the lab include:
Integration of chemical proteomics and phosphoproteomics to understand mechanisms of complex kinase inhibitors
Mapping cancer networks using affinity purification and mass spectrometry
Mechanisms of action of Src kinase inhibitors and translation to early phase clinical trials
Role of interleukin-6 and STAT3 pathway in control of lung cancer growth, survival, angiogenesis, and metastasis
Profiling tyrosine phosphorylation in lung cancer