R. Del Valle, Ph.D.
of Oncologic Sciences
of South Florida
Magnolia Drive, MRC-3East
H. Lee Moffitt
Cancer Center and Research Institute, an NCI-designated Comprehensive
to the Del Valle Group website. Our research program is focused on new
chemical strategies to elucidate structure-activity relationships of
peptides and small molecules. Our overall goal is to bring the power of
modern organic chemistry to bear on current challenges in biomedicine.
Please click on the above tabs for more information.
- August 19, 2014 Welcome to our new graduate student, Matthew Sarnowski!
- August 18, 2014 Our manuscript on the synthesis and SAR of novel peptidomimetic Akt inhibitors was accepted for publication in Bioorganic Medicinal Chemistry Letters.
- April 21, 2014 Our
manuscript entiteld "Synthesis of novel tricyclic chromenone inhibitors
of IRE-1 RNase activity" was accepted for publication in the Journal of Medicinal Chemistry and is now online. Congratulations to Sujeewa, Chang Won, and Bernie!
- March 25, 2014 Our
manuscript in collaboration with Hu lab, entitled "Inhibition of ER
stress-associated IRE-1/XBP-1 pathway reduces leukemic cell
accepted for publication in The Journal of Clinical Investigation!
- February 12, 2014 The
lab thanks the Moffitt Research Institute and CCSG for a Team Science
Grant in support of our reseach. The Del Valle and Hu labs were jointly
funded based on a proposal to develop IRE-1/XBP-1 inhibitors for the
treatment of CLL.
- February 11, 2014 Our
paper on the synthesis of novel covalent inhibitors of IRE-1 RNase activity was submitted for publication.
- September 25, 2013 Our
paper in collaboration with the Hu lab on genetic and pharmacological
blockade of XBP-1s expression in cancer was submitted for review. Stay
tuned for updates.
- April 23, 2013 Congratulations
to Chang Won and Young, who both recieved Travel Awards to present
their work at the 2013 American Peptide Society Symposium in June.
- November 30, 2012 Our
paper on the design and synthesis of novel beta-strand mimics based on imidazo[1,2-a]pyridines was accepted for publication in Organic Letters. Congratulations to Chang Won and Yongmao!
- October 5, 2012 Our
papers on the first total synthesis of lucentamycin A and on revision
of its structure through spectroscopic analysis have been accepted in
the Journal of Organic Chemistry and the Journal of Natural Products. Congratulations to Sujeewa! See the Publications
page for details/links.
September 21, 2012 The
lab was awarded an NIH R21 grant from the National Cancer Institute to
develop novel protein-protein interaction inhibitors targeting the Akt
September 7, 2012 Our
recently published article on an ester enolate-Claisen rearrangement
route to polysubstituted prolines was highlighted in an ACS Virtual Issue on Peptide Chemistry.
- July 13, 2012 Our paper
on the synthesis of novel
hexahydronaphthalene-based inhibitors of Mcl-1
was accepted for publication in Bioorganic and
Medicinal Chemistry Letters.
Congratulations to Young!
June 13, 2012 Our
article in collaboration with the Hu Lab at
Moffitt, entitled "Overexpression of TCL1
activates endoplasmic reticulum stress response:
A novel mechanism of leukemic progression in
mice", was published online ahead of print in Blood.
April 5, 2012 Congratulations
to Dr. Sujeewa Ranatunga, who successfully
defended his Ph.D. thesis entitled "Design and
synthesis of biologically relevant substituted
October 7, 2011 Three
of our recently accepted manuscripts are now
online, ahead of print. See the Publications
page for details and links.
23, 2011 Our
manuscript on an ester enolate-Claisen
rearrangement route to substituted
4-alkylideneprolines was accepted for
publication in the Journal of Organic
14, 2011 Our
manuscript on a Diels-Alder route to
dedhydrodecalin analogs of meiogynin A was
accepted for publication in Tetrahedron
Letters. Congratulations to Young!
13, 2011 Our
manuscript entitled "Synthesis of GSK3b mimetic
inhibitors of Akt featuring a novel extended
dipeptide surrogate" was accepted for
publication in Bioorganic and Medicinal
Chemistry Letters. Congratulations to
to Sujeewa, whose poster entitled "Exploring an ester
enolate-Claisen rearrangement route to
lucentamycin A and related
3-alkyl-4-alkylideneprolines" was awarded 2nd
place overall at the 9th Annual Castle
Conference, hosted by the USF Dept. of
13, 2010 The
lab welcomes our new Postdoctoral Fellow,
Yongmao Sun. Yongmao comes to us by way of the
National Institutes of Health and the University
of Illinois at Chicago.
to our new Postdoctoral Fellow, Chang Won Kang.
Chang Won comes to us from the University of
Texas Medical Branch and the University of South
paper entitled "Synthesis and conformational
analysis of bicyclic extended dipeptide
surrogates" was published in
the Journal of Organic Chemistry.
Congratulations to Sujeewa!
lab received a 3-year research grant from
the James and Esther King Biomedical
Research Program for our proposal entitled
"Natural Product-inspired Approached targeting
proposal entitled "Chemical and Biological
Studies of Marine-derived Non-Ribosomal
Peptides" was funded by the Bankhead-Coley
Biomedical Research Program.
paper on the synthesis of new
azabicycloalkane-based extended dipeptide mimics
was submitted for publication.
to Sujeewa, whose poster entitled "Synthesis of Akt
Inhibitors Using a Bicyclic Proline-Based
Scaffold as the Peptidomimetic Core" was
awarded 1st place at the 8th Annual Castle
Conference, hosted by the USF Dept. of
lab thanks the Miles for Moffitt Foundation for
a Milestone Award in support of new investigator
here for more information on this year's
race and fundraiser.
14, 2009 The
lab welcomes our new postdoctoral fellow, Young
B. Kim. Young comes to our lab by way of Univ.
of Mississippi and Texas A&M.
The lab welcomes Jinsoo Kim, our
new postdoctoral fellow from UC Santa Cruz.
on the total synthesis of presumed lucentamycin
A appeared in Organic Letters ASAP.
Congratulations to Pal, Sujeewa, and Yamuna!
The newly acquired automated
flash chromatography system is now up and
Our new Agilent RP-HPLC system is
After a prolonged internet
absence, our lab webpage is once again up and
proposal on inhibitors of siderocalin-induced
apoptosis is funded by the American Cancer
Society and the Moffitt Cancer Center.
Mar 20, 2009
Our manuscript on the the
synthesis of bicycloproline appeared in Tetrahedron
Letters 2009, 50, 2464.
Congratulations to Sujeewa!
Mar 1, 2009
The lab has completed its move to
the Moffitt Cancer Center on the campus of the
University of South Florida.
Welcome to Dr. Ujjwal Pal, our
new Postdoctoral Researcher.
Sep 18, 2008 Our paper
on the synthesis of carbapyochelins appeared in
the Journal of Organic Chemistry 2008,