Juan R. Del Valle, Ph.D.

Assistant Member

Drug Discovery Department

Moffitt Cancer Center

 

Affiliate Assistant Professor

Department of Chemistry

Department of Oncologic Sciences

University of South Florida

 

12902 Magnolia Drive, MRC-3East

Tampa, FL 33612

 

juan.delvalle@moffitt.org

office: MRC 3056-G

tel: 813.745.6142

fax: 813.745.6817

 

 

 

 

H. Lee Moffitt Cancer Center and Research Institute, an NCI-designated Comprehensive Cancer Center

 

 

Welcome to the Del Valle Group website. Our research program is focused on new chemical strategies to elucidate structure-activity relationships of peptides and small molecules. Please click on the above tabs for more information.

 

GROUP NEWS:

  • October 3, 2014  Our manuscript on the synthesis of constrained backbone aminated peptides was accepted for publication in Organic Letters. Congratulations to Chang Won, Sujeewa, and Matt!
  • August 19,  2014   Welcome to our new graduate student, Matthew Sarnowski!
  • August 18, 2014   Our manuscript on the synthesis and SAR of novel peptidomimetic Akt inhibitors was accepted for publication in Bioorganic Medicinal Chemistry Letters.
  • April 21, 2014   Our manuscript entiteld "Synthesis of novel tricyclic chromenone inhibitors of IRE-1 RNase activity" was accepted for publication in the Journal of Medicinal Chemistry and is now online. Congratulations to Sujeewa, Chang Won, and Bernie!
  • March 25, 2014   Our manuscript in collaboration with Hu lab, entitled "Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival"was accepted for publication  in The Journal of Clinical Investigation!
  • February 12, 2014   The lab thanks the Moffitt Research Institute and CCSG for a Team Science Grant in support of our reseach. The Del Valle and Hu labs were jointly funded based on a proposal to develop IRE-1/XBP-1 inhibitors for the treatment of CLL.
  • February 11, 2014   Our paper on the synthesis of novel covalent inhibitors of IRE-1 RNase activity was submitted for publication.
  • September 25, 2013   Our paper in collaboration with the Hu lab on genetic and pharmacological blockade of XBP-1s expression in cancer was submitted for review. Stay tuned for updates.
  • April 23, 2013   Congratulations to Chang Won and Young, who both recieved Travel Awards to present their work at the 2013 American Peptide Society Symposium in June.
  • November 30, 2012   Our paper on the design and synthesis of novel beta-strand mimics based on imidazo[1,2-a]pyridines was accepted for publication in Organic Letters. Congratulations to Chang Won and Yongmao!
  • October 5, 2012   Our papers on the first total synthesis of lucentamycin A and on revision of its structure through spectroscopic analysis have been accepted in the Journal of Organic Chemistry and the Journal of Natural Products. Congratulations to Sujeewa! See the  Publications page for details/links.
  • September 21, 2012   The lab was awarded an NIH R21 grant from the National Cancer Institute to develop novel protein-protein interaction inhibitors targeting the Akt signaling pathway.

  • September 7, 2012   Our recently published article on an ester enolate-Claisen rearrangement route to polysubstituted prolines was highlighted in an ACS Virtual Issue on Peptide Chemistry

  • July 13, 2012   Our paper on the synthesis of novel hexahydronaphthalene-based inhibitors of Mcl-1 was  accepted for publication in Bioorganic and Medicinal Chemistry Letters. Congratulations to Young!

  • June 13, 2012   Our article in collaboration with the Hu Lab at Moffitt, entitled "Overexpression of TCL1 activates endoplasmic reticulum stress response: A novel mechanism of leukemic progression in mice", was published online ahead of print in Blood. 

  • April 5, 2012   Congratulations to Dr. Sujeewa Ranatunga, who successfully defended his Ph.D. thesis entitled "Design and synthesis of biologically relevant substituted proline derivatives".

  • October 7, 2011   Three of our recently accepted manuscripts are now online, ahead of print. See the Publications page for details and links.

  • September 23, 2011   Our manuscript on an ester enolate-Claisen rearrangement route to substituted 4-alkylideneprolines was accepted for publication in the Journal of Organic Chemistry.

  • September 14, 2011   Our manuscript on a Diels-Alder route to dedhydrodecalin analogs of meiogynin A was accepted for publication in Tetrahedron Letters. Congratulations to Young!

  • September 13, 2011   Our manuscript entitled "Synthesis of GSK3b mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate" was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Congratulations to Sujeewa!

  • April 11, 2011   Congratulations to Sujeewa, whose poster entitled  "Exploring an ester enolate-Claisen rearrangement route to lucentamycin A and related 3-alkyl-4-alkylideneprolines" was awarded 2nd place overall at the 9th Annual Castle Conference, hosted by the USF Dept. of Chemistry.

  • October 13, 2010   The lab welcomes our new Postdoctoral Fellow, Yongmao Sun. Yongmao comes to us by way of the National Institutes of Health and the University of Illinois at Chicago.

  • July 26, 2010   Welcome to our new Postdoctoral Fellow, Chang Won Kang. Chang Won comes to us from the University of Texas Medical Branch and the University of South Florida.

  • July 1, 2010   Our paper entitled "Synthesis and conformational analysis of bicyclic extended dipeptide surrogates" was published in the Journal of Organic Chemistry. Congratulations to Sujeewa! 

  • June 2, 2010   The lab received a 3-year research grant from the  James and Esther King Biomedical Research Program for our proposal entitled "Natural Product-inspired Approached targeting Mcl-1". 

  • June 1, 2010   Our proposal entitled "Chemical and Biological Studies of Marine-derived Non-Ribosomal Peptides" was funded by the Bankhead-Coley Biomedical Research Program.

  • April 29, 2010   Our paper on the synthesis of new azabicycloalkane-based extended dipeptide mimics was submitted for publication.

  • April 22, 2010   Congratulations to Sujeewa, whose poster entitled  "Synthesis of Akt Inhibitors Using a Bicyclic Proline-Based Scaffold as the Peptidomimetic Core" was awarded 1st place at the 8th Annual Castle Conference, hosted by the USF Dept. of Chemistry.

  • March 22, 2010   The lab thanks the Miles for Moffitt Foundation for a Milestone Award in support of new investigator research. Click here for more information on this year's race and fundraiser.

  • December 14, 2009   The lab welcomes our new postdoctoral fellow, Young B. Kim. Young comes to our lab by way of Univ. of Mississippi and Texas A&M.

  • November 2, 2009    The lab welcomes Jinsoo Kim, our new postdoctoral fellow from UC Santa Cruz.

  • October 28, 2009    Our manuscript on the total synthesis of presumed lucentamycin A appeared in Organic Letters ASAP. Congratulations to Pal, Sujeewa, and Yamuna!

  • October 27, 2009    The newly acquired automated flash chromatography system is now up and running.

  • August 6, 2009    Our new Agilent RP-HPLC system is installed.

  • July 6, 2009    After a prolonged internet absence, our lab webpage is once again up and running.

  • May 15, 2009   Our  proposal on inhibitors of siderocalin-induced apoptosis is funded by the American Cancer Society and the Moffitt Cancer Center.

  • Mar 20, 2009    Our manuscript on the the synthesis of bicycloproline appeared in  Tetrahedron Letters 2009, 50, 2464. Congratulations to Sujeewa!

  • Mar 1, 2009    The lab has completed its move to the Moffitt Cancer Center on the campus of the University of South Florida.      

  • Nov 6, 2008    Welcome to Dr. Ujjwal Pal, our new Postdoctoral Researcher. 

  • Sep 18, 2008   Our paper on the synthesis of carbapyochelins appeared in the Journal of Organic Chemistry 2008, 73, 7420.

 

 

 

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2008 Del Valle Lab