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Juan
R. Del Valle, Ph.D.
Assistant
Member
Drug
Discovery Department
Moffitt
Cancer Center
Affiliate
Assistant Professor
Department
of Chemistry
Department
of Oncologic Sciences
University
of South Florida
12902
Magnolia Drive, MRC-3East
Tampa,
FL 33612
juan.delvalle@moffitt.org
office:
MRC 3056-G
tel:
813.745.6142
fax:
813.745.6817
H. Lee Moffitt
Cancer Center and Research Institute, an NCI-designated Comprehensive
Cancer Center
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Our research
program is focused on new chemical strategies to
target the molecular hallmarks of cancer. Current
efforts involve a combination of protein/peptide
mimicry, natural product synthesis, and
structure-based drug design. Our overall goal is to
bring the power of modern organic chemistry to bear
on current challenges in cancer biology. Please
click on the above tabs for more information.
GROUP NEWS:
- April 23, 2013 Congratulations
to Chang Won and Young, who both recieved Travel Awards to present
their work at the 2013 American Peptide Society Symposium in June.
- November 30, 2012 Our
paper on the design and synthesis of novel beta-strand mimics based on imidazo[1,2-a]pyridines was accepted for publication in Organic Letters. Congratulations to Chang Won and Yongmao!
- October 5, 2012 Our
papers on the first total synthesis of lucentamycin A and on revision
of its structure through spectroscopic analysis have been accepted in
the Journal of Organic Chemistry and the Journal of Natural Products. Congratulations to Sujeewa! See the Publications
page for details/links.
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September 21, 2012 The
lab was awarded an NIH R21 grant from the National Cancer Institute to
develop novel protein-protein interaction inhibitors targeting the Akt
signaling pathway.
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September 7, 2012 Our
recently published article on an ester enolate-Claisen rearrangement
route to polysubstituted prolines was highlighted in an ACS Virtual Issue on Peptide Chemistry.
- July 13, 2012 Our paper
on the synthesis of novel
hexahydronaphthalene-based inhibitors of Mcl-1
was accepted for publication in Bioorganic and
Medicinal Chemistry Letters.
Congratulations to Young!
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June 13, 2012 Our
article in collaboration with the Hu Lab at
Moffitt, entitled "Overexpression of TCL1
activates endoplasmic reticulum stress response:
A novel mechanism of leukemic progression in
mice", was published online ahead of print in Blood.
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April 5, 2012 Congratulations
to Dr. Sujeewa Ranatunga, who successfully
defended his Ph.D. thesis entitled "Design and
synthesis of biologically relevant substituted
proline derivatives".
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October 7, 2011 Three
of our recently accepted manuscripts are now
online, ahead of print. See the Publications
page for details and links.
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September
23, 2011 Our
manuscript on an ester enolate-Claisen
rearrangement route to substituted
4-alkylideneprolines was accepted for
publication in the Journal of Organic
Chemistry.
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September
14, 2011 Our
manuscript on a Diels-Alder route to
dedhydrodecalin analogs of meiogynin A was
accepted for publication in Tetrahedron
Letters. Congratulations to Young!
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September
13, 2011 Our
manuscript entitled "Synthesis of GSK3b mimetic
inhibitors of Akt featuring a novel extended
dipeptide surrogate" was accepted for
publication in Bioorganic and Medicinal
Chemistry Letters. Congratulations to
Sujeewa!
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April 11,
2011 Congratulations
to Sujeewa, whose poster entitled "Exploring an ester
enolate-Claisen rearrangement route to
lucentamycin A and related
3-alkyl-4-alkylideneprolines" was awarded 2nd
place overall at the 9th Annual Castle
Conference, hosted by the USF Dept. of
Chemistry.
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October
13, 2010 The
lab welcomes our new Postdoctoral Fellow,
Yongmao Sun. Yongmao comes to us by way of the
National Institutes of Health and the University
of Illinois at Chicago.
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July 26,
2010 Welcome
to our new Postdoctoral Fellow, Chang Won Kang.
Chang Won comes to us from the University of
Texas Medical Branch and the University of South
Florida.
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July 1,
2010 Our
paper entitled "Synthesis and conformational
analysis of bicyclic extended dipeptide
surrogates" was published in
the Journal of Organic Chemistry.
Congratulations to Sujeewa!
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June 2,
2010 The
lab received a 3-year research grant from
the James and Esther King Biomedical
Research Program for our proposal entitled
"Natural Product-inspired Approached targeting
Mcl-1".
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June 1,
2010 Our
proposal entitled "Chemical and Biological
Studies of Marine-derived Non-Ribosomal
Peptides" was funded by the Bankhead-Coley
Biomedical Research Program.
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April 29,
2010 Our
paper on the synthesis of new
azabicycloalkane-based extended dipeptide mimics
was submitted for publication.
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April 22,
2010 Congratulations
to Sujeewa, whose poster entitled "Synthesis of Akt
Inhibitors Using a Bicyclic Proline-Based
Scaffold as the Peptidomimetic Core" was
awarded 1st place at the 8th Annual Castle
Conference, hosted by the USF Dept. of
Chemistry.
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March 22,
2010 The
lab thanks the Miles for Moffitt Foundation for
a Milestone Award in support of new investigator
research. Click
here for more information on this year's
race and fundraiser.
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December
14, 2009 The
lab welcomes our new postdoctoral fellow, Young
B. Kim. Young comes to our lab by way of Univ.
of Mississippi and Texas A&M.
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November
2, 2009
The lab welcomes Jinsoo Kim, our
new postdoctoral fellow from UC Santa Cruz.
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October
28, 2009
Our manuscript
on the total synthesis of presumed lucentamycin
A appeared in Organic Letters ASAP.
Congratulations to Pal, Sujeewa, and Yamuna!
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October
27, 2009
The newly acquired automated
flash chromatography system is now up and
running.
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August 6,
2009
Our new Agilent RP-HPLC system is
installed.
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July 6,
2009
After a prolonged internet
absence, our lab webpage is once again up and
running.
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May 15,
2009 Our
proposal on inhibitors of siderocalin-induced
apoptosis is funded by the American Cancer
Society and the Moffitt Cancer Center.
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Mar 20, 2009
Our manuscript on the the
synthesis of bicycloproline appeared in Tetrahedron
Letters 2009, 50, 2464.
Congratulations to Sujeewa!
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Mar 1, 2009
The lab has completed its move to
the Moffitt Cancer Center on the campus of the
University of South Florida.
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Nov 6,
2008
Welcome to Dr. Ujjwal Pal, our
new Postdoctoral Researcher.
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Sep 18, 2008 Our paper
on the synthesis of carbapyochelins appeared in
the Journal of Organic Chemistry 2008,
73, 7420.
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